[D-Pro4,D-Trp7,9] Substance P (4-11)_product_DataBase

Bioactivity	[D-Pro4,D-Trp7,9] Substance P (4-11) is a potent antagonist of Substance P (HY-P0201). [D-Pro4,D-Trp7,9] Substance P (4-11) decreases plasma aldosterone (ALDO) concentration[1].
In Vivo	[D-Pro4,D-Trp7,9] Substance P (4-11) inhibits the hypotensive effect of Substance P in anesthetized rats, the vasodilator effect in the rabbit perfused heart, relaxation induced by Substance P in dog carotid arteries contracted with noradrenaline, and stimulatory actions of Substance P in the guinea pig ileum and the guinea pig trachea[1].[D-Pro4,D-Trp7,9] Substance P (4-11) (0.3 nM/K/min; i.p. for 7 days) significantly decreases plasma aldosterone (ALDO) concentration and causes atrophy of adrenal zona glomerulosa (ZG) and its parenchymal cells[2].
Name	[D-Pro4,D-Trp7,9] Substance P (4-11)
CAS	81039-85-2
Shortening	PQQWFWLM-NH2
Formula	C57H75N13O10S
Molar Mass	1134.35
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Mizrahi J, et al. Substance P antagonists active in vitro and in vivo. Eur J Pharmacol. 1982 Aug 13;82(1-2):101-5. [2]. Mazzocchi G, et al. Evidence that endogenous substance-P (SP) is involved in the maintenance of the growth and steroidogenic capacity of rat adrenal zona glomerulosa. Neuropeptides. 1995 Jul;29(1):53-8.

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